富含脯氨酸突触相关蛋白SHANK1抗体
规格：1mg/1ml
英文名： SHANK 1
别名： GKAP/SAPAP interacting protein; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SHANK 1; Somatostatin receptor interacting protein; Somatostatin receptor-
分子量： 225kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Shank1
交叉反应：Human, Mouse, Rat,
富含脯氨酸突触相关蛋白SHANK1抗体细胞定位：
产品介绍：background: The mechanisms underlying the molecular assemblage of molecules at the synapse are not well understood. Recently, a number of novel anchoring/scaffold proteins that are associated with postsynaptic density (PSD) proteins have been isolated. SHANK1, SHANK2 and SHANK3 constitute a family of proteins that may function as molecular scaffolds in the PSD. SHANK is made of five domain/regions that are probably involved in protein-protein interactions: ankyrin repeats, an SH3 domain, a PDZ domain, a SAM domain, and a proline rich region. SHANK interacts directly with GKAP or SAPAP via its PDZ domain, thus potentially bridging the N-methyl-D-aspartate receptor (NMDA)-PSD-95-GKAP complex. 富含脯氨酸突触相关蛋白SHANK1抗体Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Subunit: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2. Subcellular Location: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2. Tissue Specificity: Expressed in brain particularly in the amygdala, hippocampus, 富含脯氨酸突触相关蛋白SHANK1抗体substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously. Similarity: Belongs to the SHANK family. Contains 6 ANK repeats. Contains 1 PDZ (DHR) domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain. Gene ID: 50944 Database links: Entrez Gene: 50944 Human Entrez Gene: 243961 Mouse Entrez Gene: 78957 Rat Omim: 604999 Human SwissProt: Q9Y566 Human SwissProt: D3YZU1 Mouse SwissProt: Q9WV48 Rat Unigene: 274255 Human Unigene: 360368 Mouse Unigene: 225968 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 有学者认为：shank-1似乎是具有兴奋性突触PSD中的连接蛋白，它可以连接后突触膜受体，包括NMDA-Type和谷氨酸受体等。在树突旋转和突触连接的有机体功能和结构方面起重要作用。shank1 主要表达在脑组织内，属于shank家族。
富含脯氨酸突触相关蛋白SHANK1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid