D型-过氧化酶活化增生受体抗体
规格：1mg/1ml
英文名： PPAR delta + beta
别名： FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PPAR-del
交叉反应：Human, Mouse, Rat,
D型-过氧化酶活化增生受体抗体细胞定位：
产品介绍：background: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain. Function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene.D型-过氧化酶活化增生受体抗体 Decreases expression of NPC1L1 once activated by a ligand. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous with maximal levels in placenta and skeletal muscle. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Gene ID: 5467 Database links: Entrez Gene: 5467 Human Entrez Gene: 19015 Mouse Entrez Gene: 25682 Rat Omim: 600409 Human SwissProt: Q03181 Human SwissProt: P35396 Mouse Unigene: 696032 Human Unigene: 328914 Mouse Unigene: 96181 Rat Important Note: D型-过氧化酶活化增生受体抗体This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 类固醇受体（Steroid Receptors） 研究人员指出该分子的功能，极可能就是阻断心血管**发炎反应的讯号传递过程。PPAR－delta基因是控制肌肉发展的重要基因，在增加老鼠耐力的同时还能帮助它燃烧掉脂肪，研究人员发现，对于与新陈代谢有关的各项**，从心脏病到肥胖症都有启发性的意义，他可以阻止脂肪沉淀在动脉壁上，进而防止动脉硬化症的发生,该蛋白参与脂肪代谢、肥胖、糖尿病、动脉硬化和癌症的发病。 在动脉硬化现象发生的早期，**细胞会促使血管慢性的发炎，因而造成血管不断地吸收和输送脂肪，进而导致脂肪的堆积与血管硬化，而PPAR-delta就像警卫分子一样，时时降低发炎反应和抑制动脉硬化斑的形成，因此该分子应该是相关**研发，相当值得切入的目标。 研究人员认为，这个发现将给药厂研发**心血管**的新药提供新的线索。
D型-过氧化酶活化增生受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 **学 细胞膜受体
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid