髓鞘相关糖蛋白a/b抗体
规格：1mg/1ml
英文名： MAG
别名： GMA; MAG; MAG_HUMAN; Myelin associated glycoprotein; Myelin-associated glycoprotein; S MAG; Siglec 4a; Siglec-4a; SIGLEC4A.
分子量： 67kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAG-a/b
交叉反应：Human, Mouse, Rat,
髓鞘相关糖蛋白a/b抗体细胞定位：细胞膜
产品介绍：background: MAG (myelin associated glycoprotein) is a Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha2,3-linked sialic acid. Isoform L-MAG is critical for the formation of myelin in the CNS, whereas isoform S-MAG is sufficient to maintain the integrity of myelin in PNS. Binds to RTN4R. single-pass type I membrane protein. Expressed by myelinating glial cells in the central and peripheral nervous system. Detected in oligodendrocyte processes before formation of compact myelin. Restricted to the periaxonal space after myelination. Isoform S-MAG is the predominant isoform in CNS and PNS of the *****. In CNS isoform L-MAG is the major form synthesized early in development, and it persists as a significant proportion of the MAG 髓鞘相关糖蛋白a/b抗体present in the *****. In the PNS isoform L-MAG is expressed at modest levels during development; it is absent in the *****. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Function: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid. Subunit: Binds to RTN4R. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 4 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Gene ID: 4099 Database links: Entrez Gene: 4099 Human Entrez Gene: 17136 Mouse Entrez Gene: 29409 Rat Omim: 159460 Human SwissProt: P20916 Human SwissProt: P20917 Mouse SwissProt: P07722 Rat Unigene: 643440 Human Unigene: 241355 Mouse Unigene: 87331 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.髓鞘相关糖蛋白a/b抗体 髓鞘相关糖蛋白a/b（MAG-a/b）又称：髓磷脂相关的球蛋白 髓鞘相关糖蛋白(myelin-associated glycoprotein, MAG)是**球蛋白超家族成员，它由**神经系统的少突胶质细胞和外周神经系统的施万细胞表达。 MAG定位于直接和轴突相接触的髓鞘膜的*里层，它通过介导胶质细胞与轴突的相互作用参与髓鞘的形成及其完整性的维持。同时MAG也是髓鞘来源的神经生长抑制因子的主要成分。在神经系统发育的不同阶段，MAG显示不同的功能:即发育期促进轴突生长，成熟期抑制轴突生长。其抑制作用主要由髓鞘来源的抑制分子的共同受体NgR介导，在神经营养因子受体p75NTR以及小GTP酶Rho等信号分子的共同参与下完成。
髓鞘相关糖蛋白a/b抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid