蛋白激酶锚定蛋白抗体
规格：1mg/1ml
英文名： Neurobeachin
别名： A-kinase anchor protein 550; d AKAP 550; Neurobeachin protein; Rugose protein; AKAP550; NBEA_DROME.
分子量： 395kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Fruit fly Neur
交叉反应：Fruit Fly,
蛋白激酶锚定蛋白抗体细胞定位：
产品介绍：background: Neurobeachin binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. It may anchor the kinase to cytoskeletal and/or organelle-associated proteins. Neurobeachin, is also a neuron-specific multidomain protein of 327 kDa with a high-affinity binding site for the type II regulatory subunit of protein kinase A. Neurobeachin is peripherally associated with pleomorphic tubulovesicular endomembranes near the trans sides of Golgi stacks and throughout the cell body and cell processes. It is also found in a subpopulation of synapses, where it is concentrated at the postsynaptic plasma membrane. Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal 蛋白激酶锚定蛋白抗体pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Subunit: Interacts with RII subunit of PKA and components of the EGFR-mediated and Notch-mediated signaling pathways. Subcellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Tissue Specificity: In early embryos, ubiquitous expression with elevated levels in ventral furrow and flanking mesectodermal cells, neuroblasts and mesoderm. Late embryos show reduced expression in epidermis and skeletal muscle and elevated in nervous system, gut endothelium, tracheal system and salivary gland. Larvae show expression in imaginal disks and many neural cells. 蛋白激酶锚定蛋白抗体Developing eye imaginal disk shows expression throughout the disk and in the region of the morphogenetic furrow. Ubiquitous expression in *****s with higher levels in head region. Similarity: Belongs to the WD repeat neurobeachin family. Contains 1 BEACH domain. Contains 5 WD repeats. Database links: Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. AKAP位于心肌细胞膜浆面L型Ca2+通道旁边，通过锚定PKA，使其能迅速磷酸化Ca2+通道。有实验证明：当阻断PKA与AKMP的结合时，PKA对Ca2+通道的磷酸化作用就被阻断，说明AKMP锚定作用的关键性。
蛋白激酶锚定蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid