叉头蛋白P3抗体
规格：1mg/1ml
英文名： FoxP3
别名： AIID; AIID; DIETER; DIETER; Forkhead box P3; Forkhead box protein P3; foxp3; foxp3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocri
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FoxP3
交叉反应：Human, Mouse, Rat,
叉头蛋白P3抗体细胞定位：细胞核
产品介绍：background: The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Function: Probable transcription factor. Plays a critical role in the control of immune response. Subunit: Interacts with IKZF3. 叉头蛋白P3抗体Subcellular Location: Nucleus (Potential). Post-translational modifications: Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1. DISEASE: Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, 叉头蛋白P3抗体trombocytopenia, anemia and eczema. It is usually lethal in infancy. Similarity: Contains 1 C2H2-type zinc finger. Contains 1 fork-head DNA-binding domain. Gene ID: 50943 Database links: Entrez Gene: 50943 Human Entrez Gene: 20371 Mouse Entrez Gene: 317382 Rat Omim: 300292 Human SwissProt: Q9BZS1 Human SwissProt: Q99JB6 Mouse SwissProt: D3ZKI1 Rat Unigene: 247700 Human Unigene: 182291 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 叉头蛋白3(FOXP3)是FOX蛋白家族成员之一,主要为T细胞转录蛋白，主要表达于T细胞+CD4+CD25,并调节该类T细胞的发育和功能. FOXP3的表达受转化生长因子-β雌**和糖皮质**等调节,通过竞争性抑制活化T细胞核因子的转录活性而发挥作用.自身**性糖尿病患者体内CD4+CD25+T细胞减少,诱导FOXP3的表达或过继转移CD4+CD25+T细胞有可能预防自身**性糖尿病
叉头蛋白P3抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid