锌指蛋白231抗体
规格：1mg/1ml
英文名： Bassoon
别名： Bassoon; BSN; KIAA0434; Neuronal double zinc finger protein; Presynaptic cytomatrix protein; Protein bassoon; Zinc finger protein 231; ZNF 231; ZNF231; Neuronal double zinc finger protein; Zinc-finger
分子量： 432kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BSN (290
交叉反应：Human, Mouse, Rat,
锌指蛋白231抗体细胞定位：细胞浆 细胞膜
产品介绍：background: Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]. Function: Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1.锌指蛋白231抗体 Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses. Subunit: Interacts with ERC2/CAST1, RIMS1 and UNC13A. Part of a complex consisting of ERC2, RIMS1 and BSN. Subcellular Location: Cytoplasm. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density. Tissue Specificity: Exclusively expressed in brain. Post-translational modifications: Myristoylated. The N-terminal myristoylation is not sufficient for 锌指蛋白231抗体presynaptic localization. Gene ID: 8927 Database links: Entrez Gene: 8927 Human Entrez Gene: 12217 Mouse Entrez Gene: 29138 Rat Omim: 604020 Human SwissProt: O43161 Human SwissProt: Q9UPA5 Human SwissProt: O88737 Mouse SwissProt: O88778 Rat Unigene: 194684 Human Unigene: 20425 Mouse Unigene: 29999 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 锌指蛋白是80年代中期发现的一类DNA结合蛋白，在真核生物中,锌指蛋白可能是*大的一类DNA结合蛋白，并且由锌指蛋白调控基因表达是发育和其他过程的一个非常普遍的现象。在*近的几年中，发现某些锌指蛋白对肌肉的发育具有重要的调节作用。
锌指蛋白231抗体产品应用：IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 锌指蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid