干燥症SSB/La抗体
规格：1mg/1ml
英文名： SSB
别名： SSB; Lupus La protein homolog; La ribonucleoprotein; La autoantigen homolog; Sjogren syndrome type B antigen; LA_HUMAN.
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SSB
交叉反应：Human,
干燥症SSB/La抗体细胞定位：
产品介绍：background: Lupus La protein (Sjogren syndrome type B antigen) (SS-B) (La ribonucleoprotein) (La autoantigen) plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5S, 7S, and 7-2 RNAs. The phosphorylation sites are at the C-terminal part of the protein. Sera from patients with systemic lupus erythematosus(SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign. Function: Binds to the 3' poly(U) terminii of nascent RNA 干燥症SSB/La抗体olymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. Subunit: Interacts with DDX15. May interact with RUFY1. Subcellular Location: Nucleus (Probable). Post-translational modifications: Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. The N-terminus is blocked. Similarity: Contains 1 HTH La-type RNA-binding domain. Contains 1 RRM (RNA recognition motif) domain. Gene ID: 6741 Database links: Entrez Gene: 20823 Mouse Entrez Gene: 6741 Human Entrez Gene: 20823 Mouse Entrez Gene: 干燥症SSB/La抗体81783 Rat GenBank: NP_003133.1 Human Omim: 109090 Human SwissProt: P05455 Human SwissProt: P32067 Mouse SwissProt: P38656 Rat Unigene: 632535 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 同SSA,广泛应用于各种自身**性**检测.
干燥症SSB/La抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid