**球蛋白结合蛋白-1抗体
规格：1mg/1ml
英文名： IGBP1
别名： Alpha 4; B cell signal transduction molecule alpha 4; B-cell signal transduction molecule alpha 4; bA351K23.1; CD79a binding protein 1; CD79a-binding protein 1; IBP 1; IBP1; IGBP 1; Igbp1; IGBP1_HUMAN
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Immunogl
交叉反应：Human, Mouse, Rat, Pig, Cow, Guinea Pig,
**球蛋白结合蛋白-1抗体细胞定位：细胞浆
产品介绍：background: The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]. Function: Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits. Subunit: Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and MID2. Interacts with Ubiquitin. Subcellular Location: Cytoplasm (Potential). Tissue Specificity: Ubiquitously expressed with highest **球蛋白结合蛋白-1抗体levels in heart, skeletal muscle and pancreas. Post-translational modifications: Phosphorylated. Monoubiquitination by MID1 triggers calpain-mediated cleavage and switches IGBP1 activity from protective to destructive. DISEASE: Mental retardation, X-linked, syndromic, 28 (MRXS28) [MIM:300472]: A mental retardation syndrome characterized by agenesis of the corpus callosum, coloboma of the iris and optic nerve, severe retrognathia, and intellectual deficit. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the IGBP1/TAP42 family. Contains 1 UIM (ubiquitin-interacting motif) repeat. Gene ID: 3476 Database links: Entrez Gene: **球蛋白结合蛋白-1抗体3476 Human Entrez Gene: 18518 Mouse Entrez Gene: 58845 Rat Omim: 300139 Human SwissProt: P78318 Human SwissProt: Q61249 Mouse SwissProt: O08836 Rat Unigene: 496267 Human Unigene: 7454 Mouse Unigene: 7079 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD79a表达于从前B细胞到浆细胞的整个B细胞发育阶段。 CD79a与CD79b构成B细胞受体复合体，在介导IgM从细胞内转到细胞膜上起重要作用。CD79a是B细胞常用标记物。CD79复合物是异二聚体分子，由CD79a/mb-1和CD79b/B29 组成。在B细胞表面非共价地与膜结合的**球蛋白相连，构成B细胞抗原受体。在大多数前B细胞急性**细胞白血病、B细胞系、B细胞**瘤和和某些骨髓瘤中发现有CD79a的存在。主要用于B**细胞的判断和B细胞**瘤的诊断。
**球蛋白结合蛋白-1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid