致癌基因抗体
规格：1mg/1ml
英文名： MTLC
别名： myc target 1; Myc target 1; MYCT 1 protein; Myc target in myeloid cells protein 1; Myc target protein 1; 1110020B04Rik; AI225941; AI642973; FLJ21269; MGC156309; MGC156310; Mt-Mc1; MTLC; Mtmc1; MYCT1;
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MTLC
交叉反应：Human, Mouse, Rat, Dog,
致癌基因抗体细胞定位：细胞核
产品介绍：background: MTLC is a 235 amino acid nuclear protein that is thought to regulate certain myc target genes. Downregulated in gastric cancer tissues, MTLC is expressed in the hepatocellular carcinoma cell line, Bel7402. Overexpression of MTLC is thought to influence tumorigenic conversion, promotion of apoptosis genomic instability and inhibition of hematopoietic differentiation. The gene encoding MTLC maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of 致癌基因抗体chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. Function: May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. Subcellular Location: Nucleus. Note=Expressed in nuclei of hepatocellular carcinoma cell line致癌基因抗体 Bel7402 cells. Tissue Specificity: Down-regulated in gastric cancer tissues. Similarity: Belongs to the MYCT1 family. Gene ID: 80177 Database links: Entrez Gene: 80177 Human Entrez Gene: 68632 Mouse Entrez Gene: 292264 Rat SwissProt: Q8N699 Human SwissProt: Q8R411 Mouse Unigene: 18160 Human Unigene: 338242 Mouse Unigene: 55418 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子（Transcriptin Regulators）
致癌基因抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 染色质和核信号 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid