葡萄糖转运蛋白2抗体
规格：1mg/1ml
英文名： GLUT2
别名： liver; Glucose Transporter 2; Glucose Transporter GLUT2; Glucose transporter type 2; Glucose transporter type 2 liver; GLUT-2; GLUT2; GLUT 2; GTR2_HUMAN; SLC2A2; Solute carrier family 2 (facilitated g
分子量： 54kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GLUT2 (4
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
葡萄糖转运蛋白2抗体细胞定位：细胞膜
产品介绍：background: Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008]. Function: Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Liver, insulin-producing beta cell, small intestine and kidney. 葡萄糖转运蛋白2抗体Post-translational modifications: N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. DISEASE: Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS) [MIM:227810]. FBS is a rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.葡萄糖转运蛋白2抗体 Gene ID: 6514 Database links: Entrez Gene: 6514 Human Entrez Gene: 20526 Mouse Entrez Gene: 25351 Rat Omim: 138160 Human SwissProt: P11168 Human SwissProt: P14246 Mouse SwissProt: P12336 Rat Unigene: 167584 Human Unigene: 18443 Mouse Unigene: 89295 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 交换和转运（Trafficking and Transport） 葡萄糖载运蛋白2 GLUT-2是胰岛B细胞膜上的转运蛋白，在血糖浓度升高时，促进GLUT2对葡萄糖的转运功能，继而刺激胰岛素释放。GLUT2分子对葡萄糖亲合力极低，似乎仅在血浆葡萄糖水平相对较高时才作为转运体发挥载体功能,GLUT2在胰岛B细胞的葡萄糖转运中起着重要作用 GLUT-2和GLUT-4蛋白这两个葡萄糖运载体的研究对于糖尿病的胰岛素释放障碍和胰岛素抵抗有重要意义
葡萄糖转运蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid