Runx3抗体
规格：1mg/1ml
英文名： Runx3
别名： This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYG
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Runx3 (1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow,
Runx3抗体细胞定位：细胞核 细胞浆
产品介绍：background: RUNX3 binds to the core site of murine Leukemia virus, the core sequences in the enhancer of the polyomavirus, and also to the enhancers of the T-cell receptor genes. May be involved in the control of cellular proliferation and/or differentiation (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain.DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1, Subcellular location in Nucleus. Function: CBF binds to the core site, 5'-PYGPYGGT-3Runx3抗体', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK. Subcellular Location: Nucleus. Cytoplasm. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Post-translational modifications: Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN. Runx3抗体Similarity: Contains 1 Runt domain. Gene ID: 864 Database links: Entrez Gene: 864 Human Omim: 600210 Human SwissProt: Q13761 Human Unigene: 170019 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 新型抑癌基因/一种新发现的抑癌基因。经研究发现,在人类胃癌细胞系和胃癌组织中普遍存在Runx3基因表达的缺失或下调,该蛋白与胃癌的发生、发展密切相关。 RUNX3基因被认为是一种新发现的抑癌基因,对胃癌细胞的生长有明显的抑制作用在胃黏膜上皮细胞调控、对脊神经节的神经发育和T细胞分化中都发挥重要作用。 随着研究的不断深入，Runx3蛋白有望成为胃癌诊断的一个新型生物学标志物和基因**靶点。
Runx3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid