血影蛋白A链非红细胞型/收缩蛋白/Spectrin α抗体
规格：1mg/1ml
英文名： Spectrin alpha chain, non-erythrocytic 1
别名： SPTN1_HUMAN; Alpha Fodrin; Spectrin-Alpha; SPEC; Spectrin, alpha, non-erythrocy tic 1 variant; Spectrin alpha chain, non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid
分子量： 272kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Spectrin
交叉反应：Human, Mouse, Rat, Dog, Cow,
血影蛋白A链非红细胞型/收缩蛋白/Spectrin α抗体细胞定位：细胞浆 细胞膜
产品介绍：background: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] Function: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the 血影蛋白A链非红细胞型/收缩蛋白/Spectrin α抗体cytoskeleton at the membrane. Subunit: Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1. Interacts with CALM and EMD. Interacts (via C-terminal spectrin repeats) with TRPC4. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. Subcellular Location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. Post-translational modifications: Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro. DISEASE: Defects in SPTAN1 are the cause of epileptic encephalopathy early infantile type 5 (EIEE5) [MIM:613477]. EIEE5 is a disorder characterized by seizures associated with hypsarrhythmia profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia. Similarity: Belongs to the spectrin family. Contains 3 EF-hand domains. Contains 1 SH3 domain. Contains 23 spectrin repeats. 血影蛋白A链非红细胞型/收缩蛋白/Spectrin α抗体Gene ID: 6709 Database links: Gene ID: 6709 Human SwissProt: Q13813 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 血影蛋白(spectrin)又称收缩蛋白，是红细胞膜骨架的主要成份,参与了细胞骨架结构的形成。但不是红细胞膜蛋白的成份,约占膜提取蛋白的30%。血影蛋白属是类似肌球蛋白的膜的外在性蛋白的一种。Spectrin α是膜里侧结构蛋白质之一，除起支持双层脂质外，还有保持红细胞外形的作用，Spectrin-α占里侧结构蛋白之60—70％。
血影蛋白A链非红细胞型/收缩蛋白/Spectrin α抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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