葡萄糖转运蛋白4抗体
规格：1mg/1ml
英文名： GLUT4
别名： insulin-responsive; Glucose transporter GLUT 4; Glucose Transporter GLUT4; Glucose transporter type 4; Glucose transporter type 4 insulin responsive; GLUT 4; GLUT-4; GLUT4; GTR4_HUMAN; kug; SLC 2A4; S
分子量： 54kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GLUT4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
葡萄糖转运蛋白4抗体细胞定位：细胞浆 细胞膜
产品介绍：background: GLUT4 is the facilitated glucose transporter expressed exclusively in adipocytes and muscle cells, and is also known as the "insulin-responsive" glucose transporter. GLUT4 translocates from an ill-defined intracellular compartment to the plasma membrane in response to insulin. The total cellular content of GLUT4 is significantly decreased in adipose cells from many patients with Type II diabetes mellitus, and animals with some types of experimental diabetes. Function: Insulin-regulated facilitative glucose transporter. Subcellular Location:葡萄糖转运蛋白4抗体 Endomembrane system. Cytoplasm > perinuclear region. Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration. Tissue Specificity: Skeletal and cardiac muscles; brown and white fat. Post-translational modifications: Sumoylated. DISEASE: Defects in SLC2A4 may be a cause of noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. Defects in SLC2A4 may be a cause of certain post-receptor defects in NIDDM. The variant in position Ile-383 is found in a small number of NIDDM patients, but seems not to be found in nondiabetic subjects. Similarity: Belongs to the葡萄糖转运蛋白4抗体 major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. Gene ID: 6517 Database links: Entrez Gene: 282359 Cow Entrez Gene: 6517 Human Entrez Gene: 20528 Mouse Entrez Gene: 25139 Rat Omim: 138190 Human SwissProt: Q27994 Cow SwissProt: Q29RP5 Cow SwissProt: P14672 Human SwissProt: P14142 Mouse SwissProt: P19357 Rat Unigene: 380691 Human Unigene: 10661 Mouse Unigene: 1314 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 葡萄糖转运蛋白-4是一种十分重要的葡萄糖转运体,与胰岛素抵抗和2型糖尿病密切相关.葡萄糖转运蛋白4在细胞内部和细胞膜之间循环流动.实现对葡萄糖的转运需要葡萄糖转运蛋白4自身的转位和活化.葡萄糖转运蛋白4与肥胖、肿瘤相关联. GLUT-2和GLUT-4蛋白这两个葡萄糖运载体的研究对于糖尿病的胰岛素释放障碍和胰岛素抵抗有重要意义.
葡萄糖转运蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 **学 信号转导 干细胞 糖尿病
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid