宫颈癌原基因1/bri3结合蛋白抗体
规格：1mg/1ml
英文名： BRI3BP
别名： BRI3-binding protein; HCCR-1; HCCR1; HCCRBP-1; I3-binding protein; Cervical cancer 1 proto-oncogene-binding protein KG19; I3-binding protein; BRI3B_HUMAN; BRI3BP.
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BRI3BP
交叉反应：Human, Mouse, Rat, Chicken, Dog, Bovine,
宫颈癌原基因1/bri3结合蛋白抗体细胞定位：细胞浆 细胞膜
产品介绍：background: BRI3BP is a 251 amino acid multi-pass membrane protein. Though widely expressed, BRI3BP is found at highest levels in brain, kidney and liver where it localizes to the endoplasmic reticulum (ER) and is involved in ER structural dynamics and mitochondrial viability. Possessing pro-apoptotic properties and the ability to potentiate drug-induced apoptosis, BRI3BP overexpression has been shown to enhance caspase-3 and mitochondrial cytochrome c release in etoposide-treated human embryonic kidney 293T cells. The gene encoding BRI3BP maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a 宫颈癌原基因1/bri3结合蛋白抗体variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders. Function: Involved in tumorigenesis and may function by stabilizing p53/TP53. Subunit: Interacts with LETMD1. Subcellular Location: Mitochondrion outer membrane; Multi-pass membrane protein (Probable). Tissue Specificity: Most abundantly expressed in brain, liver and kidney. Overexpressed in leukemia and lymphoma cell lines, as well as in various宫颈癌原基因1/bri3结合蛋白抗体 carcinomas. Gene ID: 140707 Database links: Entrez Gene: 140707 Human Entrez Gene: 76809 Mouse SwissProt: Q8WY22 Human SwissProt: Q8BXV2 Mouse Unigene: 596464 Human Unigene: 290720 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 人宫颈癌基因（HCCR）是新近确定的一种癌基因，人宫颈癌蛋白： HCCR-1和HCCR-2两种蛋白。HCCR1不仅在宫颈癌组织中表达，而且在人其他肿瘤如白血病、**瘤、乳腺癌、肾B 癌、胃癌、结肠癌、肝癌和**癌中均有过度表达，可作为肝癌及乳腺癌诊断的标志物。
宫颈癌原基因1/bri3结合蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid