金属蛋白酶组织抑制因子-3抗体
规格：1mg/1ml
英文名： TIMP-3
别名： HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; TIMP3; TIMP 3; MIG 5 protein; MIG5 protein; Protein MIG 5; SFD; Sorsby fundus dystrophy pseudoinflammatory; TIMP metallopeptidase inhibitor 3; T
分子量： 21kDa
存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TIMP-3
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
金属蛋白酶组织抑制因子-3抗体细胞定位：细胞外基质 分泌型蛋白
产品介绍：background: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]. Subunit: Interacts with EFEMP1. 金属蛋白酶组织抑制因子-3抗体Subcellular Location: Secreted, extracellular space, extracellular matrix. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. Gene ID: 7078 Database links: Entrez Gene: 7078 Human Entrez Gene: 21859 Mouse金属蛋白酶组织抑制因子-3抗体 Entrez Gene: 25358 Rat Omim: 188826 Human SwissProt: P35625 Human SwissProt: P39876 Mouse SwissProt: P48032 Rat Unigene: 644633 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） 近年来，国内外科研人员对TIMP-3的抗肿瘤作用日益被重视，学者认为：TIMP-3具有强烈促凋亡、抑制血管生成、抗肿瘤浸润作用，TIMP-3与TIMP-1、2且相互间有明显协同抗肿瘤作用
金属蛋白酶组织抑制因子-3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 神经生物学 信号转导 细胞凋亡 合成与降解
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid