死亡受体3抗体
规格：1mg/1ml
英文名： DR3
别名： Apo 3; Apo3; Apo-3; Apoptosis inducing receptor AIR; Apoptosis inducing receptor; Apoptosis mediating receptor; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP; DDR 3; DDR3; Death
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DR3 C-te
交叉反应：Human, Mouse, Rat,
死亡受体3抗体细胞定位：细胞膜 分泌型蛋白
产品介绍：background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. 死亡受体3抗体The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008] Subunit: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 9: Cell membrane; Single-pass type I membrane protein. Isoform 11: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted. Isoform 7: 死亡受体3抗体Secreted. Isoform 8: Secreted. Isoform 10: Secreted. Isoform 12: Secreted. Tissue Specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate. Similarity: Contains 1 death domain. Contains 4 TNFR-Cys repeats. Gene ID: 7818 Database links: Entrez Gene: 8718 Human Entrez Gene: 85030 Mouse Entrez Gene: 500592 Rat Omim: 603366 Human SwissProt: Q93038 Human Unigene: 462529 Human Unigene: 101198 Mouse Unigene: 106560 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 死亡受体(death receptor)已经鉴定的有DR3、DR4和DR5，DR3也称为WSL-1,Apo-3受体或TRAMP(TNFR介导的细胞凋亡蛋白质TNF-receptor apoptosis-mediating protein，TRAMP)。 肿瘤坏死因子-α受体(肿瘤坏死因子受体超家TNF-α膜受体族成员)是近年来被鉴定发现的：主要在人的多**细胞组织中。它们同属TNF／NGF受体超家族成员。
死亡受体3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid