基质金属蛋白酶-7抗体
规格：1mg/1ml
英文名： MMP7
别名： Matrilysin; Matrilysin uterine; Matrin; Matrix Metalloproteinase 7; MMP-7; MMP 7; MMP7; MPSL1; PUMP 1; Pump 1 protease; PUMP1; Uterine Matrilysin; Uterine metalloproteinase; MMP7_HUMAN.
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MMP7
交叉反应：Human, Mouse, Rat,
基质金属蛋白酶-7抗体细胞定位：细胞外基质 分泌型蛋白
产品介绍：background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity基质金属蛋白酶-7抗体 of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Subcellular Location: Secreted, extracellular space, extracellular matrix (Probable). Similarity: Belongs to the peptidase M10A family. Gene ID: 4316 Database links: Entrez Gene:基质金属蛋白酶-7抗体 4316 Human Entrez Gene: 17393 Mouse Entrez Gene: 25335 Rat Omim: 178990 Human SwissProt: P09237 Human SwissProt: Q10738 Mouse SwissProt: P50280 Rat Unigene: 2256 Human Unigene: 4825 Mouse Unigene: 10282 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） MMP7属于MMP基因家族的成员之一，MMP-7又称溶基质蛋白素(Matrilysin)，其主要功能为降解粘蛋白、纤维连结蛋白和层粘连蛋白，在肿瘤细胞突破基底膜屏障和浸润、转移中起重要作用。目前主要用于各种恶性肿瘤(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)转移、浸润的研究及用于机体各种组织的发育和修复、肿瘤发**展、炎症反应等过程中作用的研究。
基质金属蛋白酶-7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 神经生物学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid