白介素1受体相关蛋白样1前体蛋白抗体
规格：1mg/1ml
英文名： IL1RAPL1
别名： IL 1 RAPL 1; IL 1RAPL 1; IL-1-RAPL-1; IL-1RAPL-1; IL1R8; IL1RAPL 1; IL1RAPL; IL1RAPL-1; IL1RAPL1; Interleukin 1 receptor 8; Interleukin 1 receptor accessory protein like 1; Interleukin-1 receptor acce
分子量： 78kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IL1RAPL1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
白介素1受体相关蛋白样1前体蛋白抗体细胞定位：细胞浆 细胞膜
产品介绍：background: The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. Function: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Subcellular Location白介素1受体相关蛋白样1前体蛋白抗体: Cell membrane. Cytoplasm. May localize to the cell body and growth cones of dendrite-like processes. Tissue Specificity: Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver. DISEASE: Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21) [MIM:300143]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation白介素1受体相关蛋白样1前体蛋白抗体patients do not manifest other clinical signs. Similarity: Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain. Gene ID: 11141 Database links: Entrez Gene: 11141 Human Entrez Gene: 331461 Mouse Omim: 300206 Human SwissProt: Q9NZN1 Human SwissProt: P59823 Mouse Unigene: 658912 Human Unigene: 121680 Mouse Unigene: 426143 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白介素1受体相关蛋白样1前体蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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