甲状腺转录因子-2抗体
规格：1mg/1ml
英文名： FOXE1
别名： FKH L15; FKHL 15; FKHL15; Forkhead (Drosophila) like 15; forkhead (Drosophila)-like 15; forkhead box E1; Forkhead box E2; Forkhead box protein E1; Forkhead drosophila homolog like 15; Forkhead like 15
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TTF-2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
甲状腺转录因子-2抗体细胞定位：细胞核
产品介绍：background: Thyroid transcription factor 2 (TITF2; Forkhead; TH; also known as a "winged helix") . FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as monomers, are also found in the Hepatocyte nuclear factor (HNF) proteins, which provide tissue-specific gene regulation. The structure contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid甲状腺转录因子-2抗体 differentiation phenotype. May play a role in lung development and surfactant homeostasis. TISSUE SPECIFICITY: Thyroid and lung. subcellular location: Nucleus Belongs to the NK-2 homeobox family. Function: Probable transcription factor. Could be involved in thyroid gland organogenesis. Subcellular Location: Nucleus (Potential). Tissue Specificity: Detected in ***** brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas. Post-translational modifications: Phosphorylated. DISEASE: Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS) [MIM:241850]. BLS is associated with thyroid agenesis, cleft palate and choanal atresia. Similarity: Contains 1 fork-head DNA-binding domain. Gene ID: 2304 Database links: Entrez Gene: 2304 Human GenBank: NP_甲状腺转录因子-2抗体004464 Human Omim: 602617 Human SwissProt: O00358 Human Unigene: 159234 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 甲状腺转录因子-2(TTF-2)在个体发生中的表达具有高度组织特异性和发育阶段特异性,是甲状腺、腭等器官正常发育的重要调节因子。 只要用于研究TTF-2基因活动规律和表达模式发生的变化,对胚胎发育过程中器官发生和产生的影响状况。
甲状腺转录因子-2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid