钠碘转运体蛋白抗体
规格：1mg/1ml
英文名： NIS
别名： Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na+/I- cotransporter; Na+/I-symporter; NIS; SC5A5_HUMAN; SLC5A5; sodium iodide symporter; Sodium-iodide
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NIS C-te
交叉反应：Human, Mouse, Rat,
钠碘转运体蛋白抗体细胞定位：
产品介绍：background: catalyzes Na+/I- symporter activity plays a role in iodide transport and thyroid hormone generation. Human Sodium Iodide Symporter (hNIS) is responsible for iodide concentrating ability within thyroid follicular cells. It is a membrane bound glycoprotein with 13 membrane spanning domains and 14 extramembranous domains. It may represent an autoantigen in thyroid. Function: Mediates iodide uptake in the thyroid gland. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expression is primarily in thyroid tissue钠碘转运体蛋白抗体, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors. DISEASE: Thyroid dyshormonogenesis 1 (TDH1) [MIM:274400]: A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Gene ID: 6528 Database links: Entrez Gene: 6528 钠碘转运体蛋白抗体Human Entrez Gene: 114613 Rat Omim: 601843 Human SwissProt: Q92911 Human SwissProt: Q63008 Rat Unigene: 103983 Human Unigene: 584804 Human Unigene: 10505 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 钠/碘转运体蛋白-NIS，是位于甲状腺细胞基底膜上的一类膜抗原，在甲状腺对碘的主动转运过程中发挥重要作用。 钠/碘转运蛋白受甲状腺刺**(TSH)、碘、细胞因子和生长因子等多种因素的广泛调节。自身**性甲状腺**时NIS的表达发生了明显变化，患者体内出现抗NIS自身抗体。 此外，NIS还与甲状腺冷结节和先天性甲状腺机能减退等甲状腺**的发病机理密切相关，近年来得到了足够的重视。
钠碘转运体蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 通道蛋白 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid