β-酪蛋白抗体
规格：1mg/1ml
英文名： Beta casein
别名： Beta-casein; CASB; CASB_SHEEP; Casein beta; CSN 2; Csn2.
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from sheep Beta-cas
交叉反应：Sheep, Goat,
β-酪蛋白抗体细胞定位：分泌型蛋白
产品介绍：background: Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Multiple binding sites for Stat5, C/EBPb (CCAAT/enchancer-binding protein) β-酪蛋白抗体and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regulator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation. Function: Important role in determination of the surface properties of the casein micelles. Subcellular Location: Secreted. Tissue Specificity: Mammary gland specific. Secreted in milk. Similarity: Belongs to the beta-casein family. Gene ID:β-酪蛋白抗体 443391 Database links: Entrez Gene: 443391 Sheep Entrez Gene: 1447 Human Omim: 115460 Human SwissProt: P05814 Human Unigene: 2242 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. β-酪蛋白常在乳腺表达，山羊、绵羊同源 分子量：25kDa
β-酪蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid