磷酸酯酶-2Ac抗体
规格：1mg/1ml
英文名： PPP4C
别名： protein phosphatase 4/c; PP4/C; Ser/Thr-protein phosphatase 4 catalitic subunit; serine/threonine-protein phosphatase 4 catalytic subunit isoform X2; PP4C; PP4; PP X; PP-X; PP2AC; PPP4C; PP4; PP4C; PP
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PP4C
交叉反应：Human, Rat, Chicken, Dog, Rabbit,
磷酸酯酶-2Ac抗体细胞定位：细胞核 细胞浆
产品介绍：background: Protein phosphatase 4C consists of a catalytic subunit PPP4C and a regulatory subunit. PPP4R1 and belongs to the PPP phosphatase family, PP X subfamily. Protein phosphatases are involved in determining the phosphorylation state of many regulatory proteins. PPP4C is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. Function: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, 磷酸酯酶-2Ac抗体DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. Subunit: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 AND GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with 磷酸酯酶-2Ac抗体SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3. Subcellular Location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Similarity: Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily. Gene ID: 5531 Database links: Entrez Gene: 5531 Human Entrez Gene: 56420 Mouse Entrez Gene: 100009163 Rabbit Entrez Gene: 171366 Rat Omim: 602035 Human SwissProt: P60510 Human SwissProt: P97470 Mouse SwissProt: P11084 Rabbit SwissProt: Q5BJ92 Rat Unigene: 534338 Human Unigene: 41998 Mouse Unigene: 9173 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 激酶和磷酸酶（Kinases and Phosphatases） 蛋白磷酸酶-4(又称PP4或PPX)是蛋白磷酸酶2A(PP2A)家族的重要成员之一； PP-2Ac参与细胞周期,生长和分化及多细胞信号通路的调节，也用于肿瘤方面的研究。
磷酸酯酶-2Ac抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞凋亡 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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