G蛋白信号转导调节因子2抗体
规格：1mg/1ml
英文名： RGS2
别名： Basic helix-loop-helix phosphoprotein G0S8; Cell growth inhibiting protein 31; Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8 24kD; G0/G1 switch regulatory protein 8; GOS8; OTTHU
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RGS2
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,
G蛋白信号转导调节因子2抗体细胞定位：
产品介绍：background: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq]. Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. Subunit: Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha). Subcellular Location: Isoform 1: Cell membrane. CytoplasmG蛋白信号转导调节因子2抗体. Nucleus, nucleolus. Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 4: Cell membrane. Mitochondrion. Tissue Specificity: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL). Post-translational modifications: Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation G蛋白信号转导调节因子2抗体of RGS2 activity. Similarity: Contains 1 RGS domain. Gene ID: 5997 Database links: Entrez Gene: 5997 Human Entrez Gene: 19735 Mouse Entrez Gene: 84583 Rat Omim: 600861 Human SwissProt: P41220 Human SwissProt: O08849 Mouse SwissProt: Q9JHX0 Rat Unigene: 78944 Human Unigene: 28262 Mouse Unigene: 1892 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. G蛋白信号转导调节子2（RGS2）是动物机体中神经、**及外界信号刺激转导的重要信号分子，它作为G蛋白分子开关，在广泛地协调胞外刺激应答中起着重要的作用。
G蛋白信号转导调节因子2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 信号转导 生长因子和** 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid