CD24抗体
规格：1mg/1ml
英文名： CD24
别名： CD 24; CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD24 antigen; CD24 molecule; CD24_HUMAN; CD24A; GPI linked surface mucin; Heat stable antigen; HSA; Nectadrin; Signal transduce
分子量： 2.3kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD24 Pro
交叉反应：Human, Mouse, Rat,
CD24抗体细胞定位：细胞膜
产品介绍：background: This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. [provided by RefSeq, Jul 2008]. Function: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Subunit: Belongs to the CD24 family. Subcellular Location: Cell membrane. Tissue Specificity: B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on CD24抗体the surface of T-cells. Post-translational modifications: Extensively O-glycosylated. DISEASE: Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for CD24抗体susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. Similarity: Belongs to the CD24 family. Gene ID: 100133941 Database links: Entrez Gene: 100133941 Human Entrez Gene: 12484 Mouse Entrez Gene: 25145 Rat Omim: 600074 Human SwissProt: P25063 Human SwissProt: P24807 Mouse SwissProt: Q07490 Rat Unigene: 644105 Human Unigene: 721443 Human Unigene: 29742 Mouse Unigene: 6007 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经干细胞标志物 肿瘤标志物 CD24是一种低分子质量高度糖基化的黏附分子, 主要表达在造血系统. *近研究表明, 在造血系统肿瘤和一些器官的实体瘤表面可见CD24高表达。 近几年很多学者认为：CD24在前列腺癌、非小细胞肺癌、鼻咽癌、原发性肝细胞癌、胆管细胞癌、麦克尔细胞癌、神经源性肿瘤、胰腺癌、胃癌、结肠癌、肾细胞癌、B细胞**瘤、乳腺癌等肿瘤组织中表达增强, 且和肿瘤侵袭转移、复发和预后相关。
CD24抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 干细胞 细胞粘附分子 细胞表面分子 糖蛋白 细胞类型标志物 t-**细胞 b-**细胞 骨髓细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid