白细胞介素-18/干扰素γ诱导因子抗体
规格：1mg/1ml
英文名： IL-18
别名： interferon gamma-inducing factor IGIF; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; Iboctadekin; IFN gamma inducing factor; IGIF; IL 1 gamma; IL 18; IL 1g; IL1 gam
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse IL-18
交叉反应：Mouse, Rat,
白细胞介素-18/干扰素γ诱导因子抗体细胞定位：分泌型蛋白
产品介绍：background: IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the白细胞介素-18/干扰素γ诱导因子抗体 IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions. Function: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Subcellular Location: Secreted. Similarity: Belongs to the IL-1 family. Gene ID: 16173 Database links: Entrez Gene: 3606 Human Entrez Gene: 16173 白细胞介素-18/干扰素γ诱导因子抗体Mouse Omim: 600953 Human SwissProt: Q14116 Human SwissProt: P70380 Mouse Unigene: 83077 Human Unigene: 1410 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IL-18是巨噬细胞分泌的一个重要因子，它具有多种**功能，能诱导产生ＩＦＮγ，无论在病毒感染早期或特异性细胞**应答效应阶段都会出现，因此IL-18主要参与**应答及炎性细胞浸润的改变。Interleukin-18 又称inteferon-gamma inducing factor(IGIF)，在辅助T细胞的应答反应中起重要作用。IL-18和IL-1一起，既参与先天**，又是后天**的构成因素。
白细胞介素-18/干扰素γ诱导因子抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid