蛋白裂解酶（一种新的癌基因）抗体
规格：1mg/1ml
英文名： Matriptase
别名： transmembrane protease, serine 6; 1300008A22Rik; IRIDA; MATRIPTASE2; TMPRSS6.
分子量： 94kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Matripta
交叉反应：Human, Mouse, Rat,
蛋白裂解酶（一种新的癌基因）抗体细胞定位：细胞膜
产品介绍：background: The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. Subunit: Interacts with CDCP1.蛋白裂解酶（一种新的癌基因）抗体 May interact with TMEFF1. Subcellular Location: Membrane; Single-pass type II membrane protein (Probable). Similarity: Belongs to the peptidase S1 family. Contains 2 CUB domains. Contains 4 LDL-receptor class A domains. Contains 1 peptidase S1 domain. Gene ID: 164656 Database links: Entrez Gene: 164656 Human Entrez Gene: 71753 Mouse Entrez Gene: 315388 Rat Omim: 609862 Human SwissProt: 蛋白裂解酶（一种新的癌基因）抗体Q8IU80 Human SwissProt: Q9DBI0 Mouse Unigene: 370885 Human Unigene: 34056 Mouse Unigene: 214123 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 蛋白裂解酶是**种已在分子水平上辨明的、与癌症相关的跨膜丝氨酸蛋白酶。他们的研究**发现蛋白裂解酶可以诱发肿瘤。蛋白裂解酶是一种细胞膜蛋白，一直以来研究者们对这种蛋白裂解酶的致癌功能表示怀疑。 matriptase在多种上皮来源的肿瘤中均高水平表达，有学者认为：matriptase作为一种癌基因，为跨膜蛋白而且位于细胞表面，部分位于胞浆。
蛋白裂解酶（一种新的癌基因）抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 激酶和磷酸酶 合成与降解
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid