肝细胞生长因子激活物抑制剂/HGFA Inhibitor 1抗体
规格：1mg/1ml
英文名： HAI-1
别名： Hepatocyte Growth Factor Activator Inhibitor 1; Spint1; Hai1; HGFA Inhibitor 1; HAI-1; SPIT1_HUMAN.
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HAI-1
交叉反应：Human, Mouse, Rat,
肝细胞生长因子激活物抑制剂/HGFA Inhibitor 1抗体细胞定位：分泌型蛋白
产品介绍：background: HGFA Inhibitor 1 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 1 also inhibits trypsin, and MTSP-1 (Matriptase), a serine proteinase that also activates HGF. HGFB Inhibitor 1 is a splice variant of HGFA Inhibitor 1, and contains a肝细胞生长因子激活物抑制剂/HGFA Inhibitor 1抗体 16 amino acid insert after the first kringle domain, relative to the HGFA Inhibitor 1 sequence. Function: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). Subunit: Interacts with HGFAC. Subcellular Location: Secreted. Similarity: Contains 2 BPTI/Kunitz inhibitor domains. Contains 1 LDL-receptor class A domain. Contains 1 MANSC domain. Gene ID: 6692 Database links: Entrez Gene:肝细胞生长因子激活物抑制剂/HGFA Inhibitor 1抗体 6692 Human Omim: 605123 Human SwissProt: O43278 Human Unigene: 233950 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. HAI-1 是一种含两个 Kunitz 域的跨膜蛋白，可抑制由细胞膜分泌的并且以游离形式存在的 HGFA 。 HAI-1 也可以作用于其它丝氨酸蛋白酶. HAI-1 主要在胎盘、肾、胰腺、前列腺和小肠，也有报道称 HAI-1 会在肝癌中表达。
肝细胞生长因子激活物抑制剂/HGFA Inhibitor 1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 激酶和磷酸酶 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid