钙/钙调素依赖蛋白激酶2b/2γ抗体
规格：1mg/1ml
英文名： CAMK2A + CAMK2B + CAMK2D
别名： CaMK2 beta+gamma+delta; CaMK2 beta; CaMK2 gamma; CaMK2 delta; CAMK2G; Calcium/calmodulin dependent protein kinase (CaM kinase) II beta; Calcium/calmodulin dependent protein kinase II beta; Calcium/cal
分子量： 53-73kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CaMK2 be
交叉反应：Human, Mouse, Rat,
钙/钙调素依赖蛋白激酶2b/2γ抗体细胞定位：细胞浆 细胞膜
产品介绍：background: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of 钙/钙调素依赖蛋白激酶2b/2γ抗体sarcoplamic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. Subunit: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ. Subcellular Location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=In slow-twitch muscle, 钙/钙调素依赖蛋白激酶2b/2γ抗体evenly distributed between longitudinal SR and junctional SR. Tissue Specificity: Widely expressed. Expressed in ***** and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. Post-translational modifications: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain. Gene ID: 815 816 817; Database links: Entrez Gene: 815 Human Entrez Gene: 816 Human Entrez Gene: 817 Human Entrez Gene: 108058 Mouse Entrez Gene: 12322 Mouse Entrez Gene: 12323 Mouse Entrez Gene: 24245 Rat Entrez Gene: 24246 Rat Entrez Gene: 25400 Rat Omim: 114078 Human Omim: 607707 Human Omim: 607708 Human SwissProt: Q13554 Human SwissProt: Q13557 Human SwissProt: Q9UQM7 Human SwissProt: P11798 Mouse SwissProt: P28652 Mouse SwissProt: Q6PHZ2 Mouse SwissProt: P08413 Rat SwissProt: P11275 Rat SwissProt: P15791 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CaMK2b也是丝/苏氨基酸激酶的一种，同属于Ca++/钙调素依赖性蛋白质激酶家族成员。钙／钙调素依赖性蛋白激酶Ⅱb（CaMKⅡb）广泛分布于**神经系统内，参与调节神经递质的合成释放、信号转导和突触可塑性的形成以及磷酸化蛋白
钙/钙调素依赖蛋白激酶2b/2γ抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
- 温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
- 免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报