促进凋亡基因抗体
规格：1mg/1ml
英文名： CIDEB
别名： cell death activator CIDE-B; cell death-inducing DFFA-like effector B; Cide-b; CIDEB_HUMAN.
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CIDE-B C
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：
促进凋亡基因抗体产品介绍：background: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as an inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE B induces apoptosis, which is inhibited by DFF45.促进凋亡基因抗体 CIDE B is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE B is expressed mainly in liver and small intestine and at lower levels in spleen, colon, kidney, peripheral blood lymphocytes, and bone marrow. Function: Activates apoptosis. Subunit: Inhibited by DFFB. Interacts with DFFA and DFFB. Tissue Specificity: Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen. Similarity: Contains 1 CIDE-N domain. Gene ID: 27141 Database links: Entrez Gene: 27141 Human Entrez Gene: 12684 Mouse Entrez Gene: 364388 Rat Omim: 促进凋亡基因抗体604441 Human SwissProt: Q546V8 Human SwissProt: Q9UHD4 Human SwissProt: O70303 Mouse Unigene: 642693 Human Unigene: 696081 Human Unigene: 708040 Human Unigene: 466766 Mouse Unigene: 204016 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CIDE-B(DFF45)是凋亡信号通路中新近发现的促进凋亡的基因，在细胞凋亡中有重要的作用，有学者认为：CIDE-B在周围神经元损伤后,脊髓内CIDE-B即可表达增强，诱导神经元凋亡； 若阻断CIDE-B的表达，能有效抑制神经元的凋亡。cide-b在肿瘤方面研究也日趋增多，他的抑制可能与肿瘤的发生有关。
促进凋亡基因抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 细胞凋亡 转运蛋白 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid