Ⅴ型胶原抗体
规格：1mg/1ml
英文名： Collagen V
别名： Collagen Type V; AB collagen; Alpha 1 type V collagen; Alpha 2 type V collagen; Col5A1; Col5A2; COL5A2 protein; Col5A3; Collagen alpha 1(V) chain; Collagen alpha 2 (V) chain precursor; Collagen alpha
分子量： 153kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Collagen
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
Ⅴ型胶原抗体细胞定位：细胞外基质 分泌型蛋白
产品介绍：background: This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]. Function: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Subunit: Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4. Subcellular Location: Secreted,Ⅴ型胶原抗体 extracellular space, extracellular matrix. Post-translational modifications: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Sulfated on 40% of tyrosines. DISEASE: Ehlers-Danlos syndrome 1 (EDS1) [MIM:130000]: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry. Ehlers-Danlos syndrome 2 (EDS2) [MIM:130010]: Mild form of classic Ehlers-Danlos syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity:Ⅴ型胶原抗体 Belongs to the fibrillar collagen family. Contains 1 fibrillar collagen NC1 domain. Contains 1 laminin G-like domain. Gene ID: 1289 Database links: Entrez Gene: 1289 Human Entrez Gene: 1290 Human Entrez Gene: 50509 Human Omim: 120190 Human Omim: 120215 Human Omim: 120216 Human SwissProt: P05997 Human SwissProt: P20908 Human SwissProt: P25940 Human SwissProt: Q15094 Human SwissProt: Q53WR4 Human SwissProt: Q5PR22 Human SwissProt: Q5SY11 Human SwissProt: Q86XF6 Human Unigene: 210283 Human Unigene: 235368 Human Unigene: 445827 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Ⅴ型胶原抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid