Ⅹ型胶原抗体
规格：1mg/1ml
英文名： Collagen X
别名： Collagen type X; Col10a 1; Collagen alpha 1(X) chain; Collagen type X alpha 1 (Schmid metaphyseal chondrodysplasia); Collagen type X alpha 1; Collagen X alpha 1 polypeptide; CollagenX; fa66d11; fb10c0
分子量： 73kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Collagen
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,
细胞定位：
Ⅹ型胶原抗体产品介绍：background: This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). [provided by RefSeq, Jul 2008]. Function: Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. Subunit: Homotrimer. Subcellular Location: Secreted, extracellular space, extracellular matrix. Ⅹ型胶原抗体Tissue Specificity: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. DISEASE: Schmid type metaphyseal chondrodysplasia (SMCD) [MIM:156500]: Dominantly inherited disorder of the osseous skeleton. The cardinal features of the phenotype are mild short stature, coxa vara and a waddling gait. Radiography usually shows sclerosis of the ribs, flaring of the metaphyses, and a wide irregular growth plate, especially of the knees. A variant form of SMCD is spondylometaphyseal dysplasia Japanese type. It is characterized by spinal involvement comprising mild platyspondyly, vertebral body abnormalities, and end-plate irregularity. Note=The disease is caused by mutationsⅩ型胶原抗体 affecting the gene represented in this entry. Similarity: Contains 1 C1q domain. Gene ID: 1300 Database links: Entrez Gene: 282416 Cow Entrez Gene: 1300 Human Entrez Gene: 12813 Mouse Entrez Gene: 25681 Rat Omim: 120110 Human SwissProt: P23206 Cow SwissProt: A1L4P2 Human SwissProt: Q03692 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Ⅹ型胶原是一种短链的非纤维性胶原，正常存在于软骨化骨中心及骨骺软骨生长板内，仅见于软骨细胞肥大区及钙化区前沿，在关节软骨见于钙化软骨层，由肥大软骨细胞特异表达，只短暂出现，可能参与软骨钙化的调节，是正常和异常骨形成的标志。 有学者认为：Ⅹ型胶原在骨性关节病中可作为软骨细胞表型不可逆转的诊断标志 ，是大量关节软骨细胞发生凋亡，*终导致关节软骨变薄，关节下骨变硬、增厚的主要原因。
Ⅹ型胶原抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid