P选择素/白细胞内皮细胞粘附分子3抗体
规格：1mg/1ml
英文名： CD62p
别名： CD62 antigen-like family member P; GMP 140; GMP-140; GMRP; Granule membrane protein 140; Granulocyte membrane protein; GRMP; LECAM 3; LECAM3; Leukocyte endothelial cell adhesion molecule 3; Leukocyte-
分子量： 88kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human P-select
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
P选择素/白细胞内皮细胞粘附分子3抗体细胞定位：细胞膜
产品介绍：background: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008] Function: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Subunit: Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 P选择素/白细胞内皮细胞粘附分子3抗体and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. DISEASE: Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of P选择素/白细胞内皮细胞粘附分子3抗体motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Similarity: Belongs to the selectin/LECAM family. Contains 1 C-type lectin domain. Contains 1 EGF-like domain. Contains 9 Sushi (CCP/SCR) domains. Gene ID: 6403 Database links: Entrez Gene: 6403 Human Entrez Gene: 20344 Mouse Entrez Gene: 25651 Rat Omim: 173610 Human SwissProt: P16109 Human SwissProt: Q01102 Mouse SwissProt: P98106 Rat Unigene: 73800 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. P-选择素(P—selectin)是细胞黏附分子选择素家族的主要成员，又称CD62p，可以介导各种白细胞和肿瘤细胞的粘附。 CD62p又称GMP—140或PADGEM蛋白(血小板活化依赖α颗粒膜蛋白),它在血小板与单核细胞及中性粒细胞相互作用中起关键作用。
P选择素/白细胞内皮细胞粘附分子3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 干细胞 细胞粘附分子 上皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid