细胞表面趋化因子受体2抗体
规格：1mg/1ml
英文名： CCR-2
别名： C-C Chemokine receptor 2B; C C chemokine receptor type 2; C C CKR 2; CC chemokine receptor type 2; CC CKR 2; CCCKR2; CCR 2; CCR1L; CCR2A; CCR2B; CCR5L; CD192; CD192 antigen; Chemokine C C motif recept
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CCR-2
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞表面趋化因子受体2抗体细胞定位：细胞膜
产品介绍：background: This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript细胞表面趋化因子受体2抗体 variants are expressed by the gene. [provided by RefSeq, Mar 2009]. Function: Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Subunit: Binds to HIV-1 Tat. Interacts with ARRB1. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: N-glycosylated. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 729230 Database links: Entrez Gene: 729230 Human Entrez Gene: 12772 Mouse Entrez Gene: 60463 Rat Omim: 601267 Human SwissProt: P41597 Human SwissProt: P51683 Mouse SwissProt: O55193 Rat Unigene: 511794 Human细胞表面趋化因子受体2抗体 Unigene: 705362 Human Unigene: 6272 Mouse Unigene: 211983 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CCR-2是属于G蛋白偶联受体一家族，参与调节白细胞的迁移和活性作用，是细胞膜蛋白，它的变异与HIV-1抵抗有关。CCR-2不仅在宫颈癌组织中表达，而且在人其他肿瘤如白血病、**瘤、乳腺癌、肾B 癌、胃癌、结肠癌、肝癌和**癌中均有过度表达，可作为肝癌及乳腺癌诊断的标志物。
细胞表面趋化因子受体2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid