整合素α5抗体Integrin α5
规格：1mg/1ml
英文名： Integrin alpha 5
别名： Alpha 5 beta 1; CD49 antigen-like family member E; CD49e; ECMRVI; Fibronectin Receptor alpha; Fibronectin receptor alpha subunit; Fibronectin receptor, alpha subunit; FNR; FNRA; gpIc/IIa; Integrin alp
分子量： 110kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Integrin
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：细胞膜
整合素α5抗体Integrin α5产品介绍：background: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008] Function: CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha 整合素α5抗体Integrin α5chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV-1 Tat. Subcellular Location: 整合素α5抗体Integrin α5Membrane; Single-pass type I membrane protein. Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Gene ID: 3678 Database links: Entrez Gene: 3678 Human Entrez Gene: 16402 Mouse Entrez Gene: 315346 Rat Omim: 135620 Human SwissProt: P08648 Human SwissProt: P11688 Mouse Unigene: 505654 Human Unigene: 16234 Mouse Unigene: 100796 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ITG-α5粘附分子整合素α5也是细胞粘附分子的超家族成员，广泛分布于细胞表面和细胞外基质的糖蛋白,不仅介导细胞与细胞或细胞与基质之间的连接,而且参与细胞间的信号转导,细胞的生长移行,肿瘤的转移浸润,**炎性反应,血管生成等一系列的生理和病理过程。
整合素α5抗体Integrin α5产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 干细胞 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid