膜粘连蛋白 Ⅱ抗体
规格：1mg/1ml
英文名： Annexin A2
别名： Annexin A2; ANX 2; ANX2; ANX2L4; ANXA2; arylsulfatase B; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide (p36); chromobindin 8; LIP2; Lipocortin II; LPC2; LPC2D; P36; P36 protein; PAP-IV
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Annexin
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Sheep,
细胞定位：细胞浆 细胞膜 细胞外基质 分泌型蛋白
膜粘连蛋白 Ⅱ抗体产品介绍：background: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two膜粘连蛋白 Ⅱ抗体 calcium ions with high affinity. May be involved in heat-stress response. Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF. Interacts with human cytomegalovirus (HCMV). Interacts with COCH. Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. Post-translational modifications: Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated. Similarity: Belongs to the annexin family. Contains 4 annexin repeats. Gene ID: 302 Database links: Entrez Gene: 膜粘连蛋白 Ⅱ抗体302 Human Entrez Gene: 12306 Mouse Entrez Gene: 56611 Rat Omim: 151740 Human SwissProt: P07355 Human SwissProt: P07356 Mouse SwissProt: Q07936 Rat Unigene: 511605 Human Unigene: 238343 Mouse Unigene: 90546 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 信号传导（Signaling Intermediates） Annexin 2是新近发现的纤维蛋白溶解酶原(PLG)和组织型纤溶蛋白溶解酶原激活物(t-PA)的共受体,是Ca2+介导具有高亲和力的磷脂结合蛋白.其介导血管内外纤维蛋白溶解,对保持机体内环境稳定具有重要作用. 依赖性膜磷脂结合蛋白Annexin II调控异常及有害因子的作用,可导致血栓性**和动脉硬化症 钙依赖性膜磷脂结合蛋白膜粘连蛋白2异常高表达所引起纤溶亢进,是白血病等恶性肿瘤出血合并症重要机制之一.钙依赖性磷脂结合蛋白对其干预和调控可能为**上述病症提供新思路,为临床**开辟新途径.
膜粘连蛋白 Ⅱ抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid