alpha 1肾上腺素能受体A抗体
规格：1mg/1ml
英文名： ADRA1A
别名： ADA1A_HUMAN; Adrenergic alpha 1A receptor; Adrenergic alpha 1C receptor; Adrenergic alpha 1D receptor; alpha 1 Adrenergic Receptor; Alpha 1A adrenergic receptor; Alpha-1A adrenergic receptor; Alpha-1A
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Alpha-1A
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
alpha 1肾上腺素能受体A抗体细胞定位：细胞核 细胞膜
产品介绍：background: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]. Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Subunit: Homo- and heterooligomer. alpha 1肾上腺素能受体A抗体Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Subcellular Location: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. Tissue Specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. Post-translational modifications: C-terminal Ser or Thr residues may be phosphorylated. Similarity: Belongs to the G-protein coupled receptor alpha 1肾上腺素能受体A抗体1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. Gene ID: 148 Database links: Entrez Gene: 148 Human Entrez Gene: 11549 Mouse Entrez Gene: 29412 Rat Omim: 104221 Human SwissProt: P35348 Human SwissProt: P97718 Mouse SwissProt: P43140 Rat Unigene: 52931 Human Unigene: 709175 Human Unigene: 57064 Mouse Unigene: 9991 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ADRA1肾上腺素能α1受体位于突触后，在血管平滑肌上，兴奋时可使血管收缩; alpha 1-adrenergic receptor有兴奋效应也有抑制效应。肾上腺素能受体又可分为α和β两种。alpha 受体与儿茶酚胺结合后，主要是兴奋平滑肌，如血管收缩、**收缩和瞳孔开张肌收缩等；但也有抑制作用，如使小肠平滑肌舒张。β受体又可分为β1和β2两个亚型.
alpha 1肾上腺素能受体A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-300 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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