阴离子转运蛋白-1抗体
规格：1mg/1ml
英文名： SLC22A6
别名： Organic anion transporter 1; OAT1; OAT-1; solute carrier family 21 (organic anion transporter), member 6; FLJ55736; HOAT1; MGC124962; MGC45260; mOat1; NKT; Oat; Orctl1; PAHT; ROAT1; SLC22A6; SO1A1_RAT
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse OAT-1
交叉反应：Mouse, Rat,
细胞定位：细胞膜
阴离子转运蛋白-1抗体产品介绍：background: Recent advances in molecular biology have identified three organic anion transporter families: the organic anion transporter (OAT) family encoded by SLC22A, the organic anion transporting peptide (OATP) family encoded by SLC21A (SLCO), and the multidrug resistance-associated protein (MRP) family encoded by ABCC. These families play critical roles in the transepithelial transport of organic anions in the kidneys as well as in other tissues such as the liver and brain. Among these families, the OAT family plays the central role in renal organic anion transport. Knowledge of these three families at the molecular level, such as substrate selectivity, tissue distribution, 阴离子转运蛋白-1抗体and gene localization, is rapidly increasing. Function: Mediates the Na(+)-independent transport of organic anions such as taurocholate, prostaglandin E2 (PGE2), dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate, sulfobromophthalein (BSP), ouabain and gadoxetate. Subunit: Binds to PDZK1. Interaction with PDZK1 is required for expression on hepatocyte surface. Subcellular Location: Basolateral cell membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in liver, and at lower levels in kidney. Not detected in 阴离子转运蛋白-1抗体other tissues. Similarity: Belongs to the organo anion transporter (TC 2.A.60) family. Contains 1 Kazal-like domain. Gene ID: 18399 Database links: Entrez Gene: 18399 Mouse Entrez Gene: 29509 Rat SwissProt: Q8VC69 Mouse SwissProt: O35956 Rat Unigene: 30090 Mouse Unigene: 87849 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
阴离子转运蛋白-1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid