B和T**细胞衰减蛋白抗体
规格：1mg/1ml
英文名： CD272
别名： B and T lymphocyte associated protein; B and T lymphocyte attenuator; B and T lymphocyte associated; BTLA; BTLA1; CD272 antigen; FLJ16065; MGC129743; BTLA_HUMAN; B- and T-lymphocyte attenuator; B- and
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human B and T-
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
B和T**细胞衰减蛋白抗体产品介绍：background: B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory B和T**细胞衰减蛋白抗体receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1). Function: Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response. Subunit: Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM. Subcellular Location: Membrane; Single-pass type I membrane protein (Potential). Post-translational modifications: Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. Gene ID: 151888 Database linksB和T**细胞衰减蛋白抗体: Entrez Gene: 151888 Human Entrez Gene: 208154 Mouse Entrez Gene: 407756 Rat Omim: 607925 Human SwissProt: Q7Z6A9 Human SwissProt: Q7TSA3 Mouse SwissProt: Q6PNM1 Rat Unigene: 445162 Human Unigene: 38199 Mouse Unigene: 124474 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. BTLA对T细胞的活化、增殖起着重要的负调控作用，BTLA相应配体为TNFR超家族中的疱疹病毒入侵介质（HVEM）, 其表达于包括T细胞在内的多种**细胞表面。 有学者将他定为CD28的超级族成员，B、T**细胞衰减子-CD272主要用于细胞信号传导方面的研究。 近来国外学者对BTLA用于抑制肿瘤方面的研究也有了新的进展，认为B、T**细胞衰减子对肿瘤的生长有抑制作用，探索新的肿瘤****有了新的途径， 封闭此途径有可能成为肿瘤****的新靶点。
B和T**细胞衰减蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 **细胞 t-**细胞 b-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid