水通道蛋白4抗体
规格：1mg/1ml
英文名： Aquaporin 4
别名： aquaporin 4; WCH4; Mercurial-insensitive water channel; MIWC; AQP 4; AQP4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; MGC22454; MIWC; AQP4_HUMAN; Aquaporin-4; AQP-4.
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AQP4
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
水通道蛋白4抗体细胞定位：细胞膜
产品介绍：background: This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. Subunit:水通道蛋白4抗体 Homotetramer. Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Brain, muscle, heart, kidney, lung, and trachea. Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family. Gene ID: 361 Database links: Entrez Gene: 281008 Cow Entrez Gene: 361 Human Entrez Gene: 11829 Mouse Entrez Gene: 25293 Rat Omim: 600308水通道蛋白4抗体 Human SwissProt: O77750 Cow SwissProt: P55087 Human SwissProt: P55088 Mouse SwissProt: P47863 Rat Unigene: 281008 Cow Unigene: 315369 Human Unigene: 250786 Mouse Unigene: 90091 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 通道蛋白（Channel Protein） 水通道蛋白(AQPs)广泛分布于机体不同组织器官中,脑组织中的水通道蛋白主要为AQP4. AQP-4蛋白主要在星型胶质细胞和室管膜细胞内表达,尤其在于****和软脑膜直接接触的胶质细胞上及血管周表达丰富. 水通道蛋白4的分布特点与其功能密切相关,可能是脑脊液重吸收、渗透压调节、脑水肿形成等生理、病理过程的分子生物学基础.研究水通道蛋白4可为脑水肿及水代谢**提供分子水平的理论依据,同时为临床**脑水肿及水代谢**提供一种新途径.
水通道蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid