粘膜血管定居因子抗体
规格：1mg/1ml
英文名： MAdCAM-1
别名： Mucosal addressin cellular adhesion molecule-1; Addressin mucosal; hMAdCAM 1; MACAM1; Mucosal addressin cell adhesion molecule 1; Mucosal vascular addressin cell adhesion molecule 1; MADCA_RAT.
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from rat MAdCAM-1
交叉反应：Mouse, Rat,
细胞定位：
粘膜血管定居因子抗体产品介绍：background: The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been 粘膜血管定居因子抗体determined. [provided by RefSeq, Jul 2008] Function: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes (By similarity). Subunit: Homodimer (Probable). Subcellular Location: 粘膜血管定居因子抗体Membrane; Single-pass type I membrane protein. Tissue Specificity: Detected in Peyer patches and mesenteric lymph nodes but not in spleen. Similarity: Contains 3 Ig-like (immunoglobulin-like) domains. Gene ID: 54266 Database links: Entrez Gene: 17123 Mouse SwissProt: Q61826 Mouse Unigene: 391556 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MAdCAM-1（粘膜血管定居因子或黏膜地址素细胞黏附分子）、CD44等均参与癌症和肿瘤细胞与血管内皮的相互作用，与癌症和肿瘤细胞一起穿过血管内皮而进入血管内，参与血行播散转移。
粘膜血管定居因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid