肝再生磷酸酯酶2抗体
规格：1mg/1ml
英文名： PTP4A2
别名： Protein tyrosine phosphatase type IV A protein 2; Protein-tyrosinephosphatase 4a2; Protein-tyrosine phosphatase of regeneratingliver 2; PTP4A2; PRL-2; PRL2; PRL 2; TP4A2_HUMAN; BM 008; EC 3.1.3.48; HH
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PRL-2
交叉反应：Human, Mouse, Rat,
细胞定位：
肝再生磷酸酯酶2抗体产品介绍：background: The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described.肝再生磷酸酯酶2抗体 Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010] Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. Subunit: In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB. Subcellular Location: Cell membrane. Early endosome. Cytoplasm. Tissue Specificity: Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue. Post-translational modifications: Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol. Similarity: Belongs to the protein-tyrosine肝再生磷酸酯酶2抗体 phosphatase family. Contains 1 tyrosine-protein phosphatase domain. Gene ID: 8073 Database links: Entrez Gene: 8073 Human Entrez Gene: 19244 Mouse Entrez Gene: 85237 Rat Omim: 601584 Human SwissProt: Q12974 Human SwissProt: O70274 Mouse SwissProt: Q6P9X4 Rat Unigene: 470477 Human Unigene: 193688 Mouse Unigene: 167750 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肝再生磷酸酯酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid