多药耐药相关蛋白3抗体
规格：1mg/1ml
英文名： MRP3
别名： ABC 31; ABC31; ABCC 3; ABCC3; ATP binding cassette sub family C (CFTR/MRP) member 3; ATP binding cassette sub family C; ATP binding cassette sub family C member 3; Canalicular multispecific organic an
分子量： 190kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MRP3 (12
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
多药耐药相关蛋白3抗体产品介绍：background: MRP3 (Canalicular Multi Organic Anion Transporter 2 / Multidrug Resistance Associated Protein 3, cMOAT2) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. The specific function of MRP3 has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Function: May act as an inducible transporter in the biliary and intestinal 多药耐药相关蛋白3抗体excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. Gene ID: 8714 Database links: Entrez Gene: 8714 Human Entrez Gene: 76408 Mouse Entrez Gene: 140668 Rat Omim: 604323 Human SwissProt: O15438 Human SwissProt: B2RX12 多药耐药相关蛋白3抗体Mouse SwissProt: O88563 Rat Unigene: 463421 Human Unigene: 23942 Mouse Unigene: 205054 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MRP3 (multidrug resistance protein 3)在正常上皮细胞：如；消化道，气管支气管，膀胱、肾上腺和睾丸组织中有不同的表达，在各种组织的基质细胞中也有程度不同的表达，在T**细胞中表达较高，而原始造血干细胞中则无表达。 MRP3又称ABCC3主要用于非P糖蛋白MDR肿瘤细胞系的肿瘤耐药性的研究。 经研究发现MRP的同源性较高，他包括：MRP1、 MRP2、MRP3、MRP4和MRP5、MRP6和MRP7，都有部分交叉同源。
多药耐药相关蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid