肺耐药相关蛋白抗体
规格：1mg/1ml
英文名： LRP/MVP
别名： 2310009M24Rik; LRP; Lung Resistance Related Protein; Lung resistance-related protein; Major Vault Protein; MVP; MVP_HUMAN; VAULT 1; VAULT1.
分子量： 99kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LRP (97-
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞核 细胞浆
肺耐药相关蛋白抗体产品介绍：background: This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated肺耐药相关蛋白抗体 STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. Subunit: The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540. Subcellular Location: Cytoplasm. Nucleus, nuclear pore complex. Tissue Specificity: Present in most normal tissues. Higher expression observed in epithelial cells肺耐药相关蛋白抗体 with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. Post-translational modifications: Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11. Similarity: Contains 9 MVP (vault) repeats. Gene ID: 9961 Database links: Entrez Gene: 9961 Human Entrez Gene: 78388 Mouse Entrez Gene: 64681 Rat Entrez Gene: 516456 Cow Omim: 605088 Human SwissProt: Q3SYU9 Cow SwissProt: Q14764 Human SwissProt: Q9EQK5 Mouse SwissProt: Q62667 Rat Unigene: 632177 Human Unigene: 228797 Mouse Unigene: 10028 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. LRP或称MVP(Major vault protein)为肺耐药相关蛋白。其耐药机制与该蛋白质参与细胞核-浆的运输有关。 他在正常细胞有广泛分布，对多种**耐药的癌细胞呈过度表达，亦属多药耐药(MDR)中的一种表型，可表达于许多肿瘤组织中，阳性者预示对化疗不敏感，主要用于各种恶性肿瘤的研究。
肺耐药相关蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid