血管生成素2抗体
规格：1mg/1ml
英文名： Angiopoietin 2
别名： AGPT 2; AGPT-2; Agpt2; ANG 2; ANG2; ANG-2; Angiopoietin 2a; Angiopoietin 2B; Angiopoietin2; Angiopoietin-2; ANGPT 2; ANGPT2; Tie2 ligand; ANGP2_HUMAN.
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Angiopoi
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig,
血管生成素2抗体细胞定位：分泌型蛋白
产品介绍：background: The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in血管生成素2抗体 the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Subunit: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. Subcellular Location: Secreted. Similarity: Contains 1 fibrinogen C-terminal domain. Gene ID: 285 Database links: Entrez Gene: 285 Human Entrez Gene: 11601 Mouse血管生成素2抗体 Entrez Gene: 89805 Rat Omim: 601922 Human SwissProt: O15123 Human SwissProt: O35608 Mouse SwissProt: O35462 Rat Unigene: 583870 Human Unigene: 439874 Mouse Unigene: 138360 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 血管生成素2(angiopoietin-2, Ang-2)是Ang家族的成员之一,是特异性血管生成刺激因子,也是恶性肿瘤早期的标志分子.
血管生成素2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid