富亮氨酸重复激酶2抗体
规格：1mg/1ml
英文名： LRRK2
别名： Dardarin; Leucine rich repeat kinase 2; LRRK 2; LRRK-2; LRRK2; PARK 8; PARK8; ROCO 2; ROCO-2; ROCO2; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; LRRK2_HUMAN; augmented in rheumato
分子量： 286kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LRRK2
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞浆 细胞膜
富亮氨酸重复激酶2抗体产品介绍：background: LRRK2 (Dardarin) is encoded by the gene LRRK2. Genetic mutations of LRRK2 have been linked to Parkinsonism and synucleinopathies. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains. Function: May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Subcellular Location: Cytoplasm. Membrane. Mitochondrion. Localized in the cytoplasm and associated with cellular membrane structures. Associates with the mitochondrial outer membrane. Tissue Specificity: Expressed throughout the ***** brain,富亮氨酸重复激酶2抗体 but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. DISEASE: Defects in LRRK2 are the cause of Parkinson disease type 8 (PARK8) [MIM:607060]. A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia 富亮氨酸重复激酶2抗体nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 12 LRR (leucine-rich) repeats. Contains 1 protein kinase domain. Contains 1 Roc domain. Gene ID: 120892 Database links: Entrez Gene: 120892 Human Entrez Gene: 66725 Mouse Entrez Gene: 300160 Rat Omim: 609007 Human SwissProt: Q5S007 Human SwissProt: Q5S006 Mouse Unigene: 187636 Human Unigene: 37558 Mouse Unigene: 213971 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 主要用于：帕金森氏病的研究 亮氨酸丰富区重复激酶2
富亮氨酸重复激酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-400 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid