胰腺衍生因子抗体
规格：1mg/1ml
英文名： FAM3B
别名： C21orf11; PANDER; Cytokine like protein 2 21; PRED44; PANcreatic DERived factor; Protein FAM3B; Protein FAM3B precursor; Family with sequence similarity 3, member B isoform a; FAM3B_MOUSE.
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FAM3B
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
胰腺衍生因子抗体产品介绍：background: FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. [Subcellular Location] Secreted. Note=Localized in discrete vesicular and perinuclear structure. Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. Belongs to the FAM3 family. Function:胰腺衍生因子抗体 Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Subcellular Location: Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure. Tissue Specificity: Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. Post-translational modifications: 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. O-glycosylated. Similarity: Belongs to the 胰腺衍生因子抗体FAM3 family. Gene ID: 52793 Database links: Entrez Gene: 54097 Human Entrez Gene: 52793 Mouse Omim: 608617 Human SwissProt: P58499 Human SwissProt: Q9D309 Mouse Unigene: 473877 Human Unigene: 670704 Human Unigene: 327932 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰腺衍生因子（PANcreatic DERived fa*ctor，PANDER）是新发现的一种新型的胰岛细胞因子、由胰岛α细胞和β细胞分泌的一种分泌型细胞因子，与β细胞凋亡密切相关 ，可以诱导胰岛素分泌β细胞，主要用于糖尿病的研究。
胰腺衍生因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 细胞凋亡 糖尿病
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid