精子相关抗原5抗体
规格：1mg/1ml
英文名： MAP126
别名： Astrin; Deepest; hMAP 126; hMAP126; MAP 126; Mitotic spindle associated protein; Mitotic spindle associated protein p126; Mitotic spindle coiled coil related protein; SPAG 5; SPAG5; Sperm associated a
分子量： 134kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPAG5
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：
精子相关抗原5抗体产品介绍：background: A novel gene product, hMAP126, interacts with p29 in the yeast two-hybrid assay. The subcellular distribution of hMAP126 was localized to the mitotic spindle and is phosphorylated by p34(cdc2) kinase. Human MAP126 is likely involved in the functional and dynamic regulation of mitotic spindles. Function: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore精子相关抗原5抗体 attachments. Subunit: Homodimer, with a globular head domain and a long stalk. Homooligomer; the globular head domains associate, resulting in aster-like structures. Binds to microtubules in the mitotic spindle. Interacts with DCLRE1B/Apollo. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2. Interacts with KNSTRN. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Note=In a punctate pattern in interphase cells. During mitosis, 精子相关抗原5抗体detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends. Tissue Specificity: Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon. Gene ID: 10615 Database links: Entrez Gene: 10615 Human SwissProt: Q96R06 Human Unigene: 16244 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
精子相关抗原5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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