色素上皮源性因子抗体
规格：1mg/1ml
英文名： PEDF
别名： pigment epithelium-derived factor; Serpin-F1; Stromal cell-derived factor 3; SDF-3; Caspin; Alpha 2 antiplasmin; EPC 1; EPC1; PIG 35; PIG35; Pigment epithelium derived factor; Proliferation inducing p
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PEDF C-t
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：分泌型蛋白
色素上皮源性因子抗体产品介绍：background: Pigment epithelium derived factor, originally identified in conditioned medium of cultured human fetal retinal pigment epithelial (RPE) cells, is a neurotrophic protein that induces extensive neuronal differentiation in human Y79 retinoblastoma cells, a neoplastic counterpart of normal retinoblasts. It has been suggested that PEDF is synthesized by RPE cells and secreted into the retina interphotoreceptor matrix where it may influence development/differentiation of the neural retina. PEDF is a potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The PEDF gene is a member of the serpin gene family. Serpins are a group of serine protease inhibitors, some of which have also been reported to exhibit neurotrophic activity. Function: Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. 色素上皮源性因子抗体Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Subcellular Location: Secreted. Melanosome. Enriched in stage I melanosomes. Tissue Specificity: Retinal pigment epithelial cells and blood plasma. Post-translational modifications: The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity. N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. DISEASE: Defects in SERPINF1 are the cause of osteogenesis imperfecta type 12 (OI12) [MIM:613982]. OI12 is a connective tissue disorder characterized by bone fragility, low bone mass, 色素上皮源性因子抗体and recurrent fractures. OI12 is characterized by features compatible with osteogenesis imperfecta type III in the Sillence classification. Patients have normal grayish sclerae and fractures of long bones and severe vertebral compression fractures, with resulting deformities observed as early as the first year of life. Similarity: Belongs to the serpin family. Gene ID: 5176 Database links: Entrez Gene: 5176 Human Entrez Gene: 20317 Mouse Omim: 172860 Human SwissProt: P36955 Human SwissProt: P97298 Mouse Unigene: 532768 Human Unigene: 2044 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 色素上皮衍生因子（PEDF）是人及动物眼中天然存在的一种糖蛋白，属于丝氨酸蛋白酶抑制剂家族，目前研究认为：它具有抗血管新生和神经营养功能的双重作用。 过去曾对PEDF的神经保护作用及抗肿瘤作用研究较多，在很多组织中都有不同的表达。 目前研究认为；PEDF是*为有效的眼内新生血管天然抑制剂，对新生血管的形成起着重要的调控作用。
色素上皮源性因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid