凋亡抑制蛋白抗体
规格：1mg/1ml
英文名： Livin
别名： Baculoviral IAP repeat containing 7; Baculoviral IAP repeat containing protein 7; BIRC 7; BIRC7; BIRC7_HUMAN; KIAP; Kidney inhibitor of apoptosis protein; LIVIN; Livin inhibitor of apotosis; Melanoma
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Livin C-
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞核 细胞浆
凋亡抑制蛋白抗体产品介绍：background: Livin is a novel member of the IAP protein family and contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin alpha and Livin beta. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. The two isoforms of Livin appear to have different functions and tissue distributions. Function: Protects against apoptosis induced by 凋亡抑制蛋白抗体TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Subcellular Location: Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm. Tissue Specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most ***** tissues. Detected in ***** heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines.凋亡抑制蛋白抗体 Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in ***** brain, skeletal muscle and peripheral blood leukocytes. Similarity: Belongs to the IAP family. Contains 1 BIR repeat. Contains 1 RING-type zinc finger. Gene ID: 79444 Database links: Entrez Gene: 79444 Human Omim: 605737 Human SwissProt: Q96CA5 Human Unigene: 256126 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Livin—属于凋亡蛋白抑制因子家族（inhibitor of apoptosis proteins，IAP） Livin是凋亡抑制蛋白家族的新成员，主要通过抑制Caspases蛋白发挥抑制细胞凋亡的作用,主要在胎盘组织中表达，同时在一些肿瘤组织中呈高表达，尤其是在黑色素瘤细胞系表达水平*高。 经研究表明，Livin与肿瘤的发生、发展关系密切,是一个有潜在价值的肿瘤标志物，此外，反义Livin以及Livin活性抑制物的研究有望成为肿瘤**的新靶点。
凋亡抑制蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞凋亡 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid