白介素12抗体
规格：1mg/1ml
英文名： IL12
别名： IL12; IL-12; CLMF p35; CLMF1; CTL maturation factor (TcMF); Cytotoxic lymphocyte maturation factor 1; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL 12 subunit p35; IL12A; Interleukin 12 al
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse IL-12
交叉反应：Mouse, Rat,
白介素12抗体细胞定位：细胞膜 分泌型蛋白
产品介绍：background: IL-12 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. 白介素12抗体This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. Subunit: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12. Subcellular Location: Secreted. Similarity白介素12抗体: Belongs to the IL-6 superfamily. Gene ID: 16159 Database links: Entrez Gene: 3592 Human Entrez Gene: 16159 Mouse Entrez Gene: 84405 Rat Omim: 161560 Human SwissProt: P29459 Human SwissProt: P43431 Mouse SwissProt: Q9R103 Rat Unigene: 673 Human Unigene: 103783 Mouse Unigene: 207199 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IL-12是新近发现的细胞因子，具有多种生物学活性，尤其是在抗肿瘤**和抗病毒**中有重要的作用。
白介素12抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid